Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  17
• Reference
  J:92699 White RA, et al., Chromosomal localization, hematologic characterization, and iron metabolism of the hereditary erythroblastic anemia (hea) mutant mouse. Blood. 2004 Sep 1;104(5):1511-8
• ID
  MGI:3581695

Genes

Gene
Ttc7
D17Mit123
Pigf

Notes

• Experiment
  The hea (hereditary erythroblastic anemia) locus was mapped using 100 homozygous mutant (hea/hea) animals from a (C57BL/6J-hea x MOLD/Rk)F1 x C57BL/6J-hea backcross. The hea phenotype showed linkage to approximately 55 cM on mouse Chromosome 17 near D17Mit123 (56.7 cM) and the Pigf gene (54.3 cM).
  
  The location of the hea mutation is in close proximity to the Ttc7^fsn flaky skin mutation at 56.2 cM. Ttc7^fsn mutants also exhibit erythropoiesis abnormalities similar to hea mutants. Complementation analysis was performed by crossing C57BL/6J-hea mutants to BALB/cByJ-Ttc7^fsn mutants. Resulting progeny all exhibit an anemic phenotype. This finding is evidence that hea and Ttc7^fsn are allelic and result from mutation within Ttc7.