Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:68580 Carnaud C, et al., Protection against diabetes and improved NK/NKT cell performance in NOD.NK1.1 mice congenic at the NK complex. J Immunol. 2001 Feb 15;166(4):2404-11
• ID
  MGI:3582431

Genes

Gene	Assay Type
Idd6	resistance/susceptibility
D6Mit254	PCR
D6Mit14	PCR
Tnfrsf1a	reported elsewhere
Clec4n	reported elsewhere

Notes

• Experiment
  A congenic strain called NOD.B6-Klrb1c was created by introgression of a C57BL/6JOrl-derived donor region containing the Idd6 locus and Klrb1c onto a NOD/Necker genetic background. The congenic region spans 10 cM on mouse Chromosome 6 from D6Mit254 (60.55 cM) to D6Mit14 (71.2 cM). At backcross generation 10 (BC10) the animals were intercrossed to establish a homozygous congenic line. Homozygous congenic animals display decreased incidence of insulin dependent diabetes. The C57BL/6JOrl-derived congenic region was observed to confer dominant resistance to diabetes in both male and female animals. Potential candidate genes for Idd6 are Tnfrsf1a (60.55 cM) and Nkcl (57 cM).