Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:99466 Ikegami H, et al., Genetic dissection of type 1 diabetes susceptibility gene, Idd3, by ancestral haplotype congenic mapping. Ann N Y Acad Sci. 2002 Apr;958:325-8
• ID
  MGI:3582715

Genes

Gene	Assay Type
Idd3	resistance/susceptibility
D3Nds36	PCR
D3Nds76	PCR
Il2	reported elsewhere

Notes

• Experiment
  From a previous study, the NOD-derived diabetes susceptibility QTL Idd3 at 19.2 cM on mouse Chromosome 3 is localized to a 0.15 cM interval between D3Nds36 and D3Nds76. A strong candidate gene named Il2 (19.2 cM) is located in this interval. In order to ascertain the diabetes susceptibility effect of an NOD-derived Il2 allele, the authors looked at NOD-related inbred strains. Four inbred strains (CTS, IIS, IOI, and NSY) shared the same Il2 allele with NOD. Among these, only inbred strain IIS contained flanking DNA different from NOD.
  
  Preliminary data from Il2 congenic animals derived from an IIS donor and NOD recipient indicate that the NOD.IIS-Il2 congenic is just as susceptible to diabetes as background strain NOD. These preliminary results suggest that NOD-derived Il2 is responsible for the diabetes susceptible effect of Idd3.