Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  X
• Reference
  J:99477 Brown AC, et al., Searching QTL by gene expression: analysis of diabesity. BMC Genet. 2005 Mar 10;6(1):12
• ID
  MGI:3582722

Genes

Gene
Bw1
Rgn
Bw3
Rab9

Notes

• Experiment
  Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes.
  
  Potential candidate genes for QTLs Bw1 (18 cM) and Bw3 (32 cM) on mouse Chromosome X as identified by ExQuest are Rgn and Rab9, respectively.