Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  15
• Reference
  J:99476 Devor M, et al., pain1: A neuropathic pain QTL on mouse chromosome 15 in a C3HxC58 backcross. Pain. 2005 Aug;116(3):289-93
• ID
  MGI:3582723

Genes

Gene	Assay Type
Pain2	visible phenotype
D15Mit68	PCR

Notes

• Experiment
  Linkage analysis was used in a backcross population of 267 (C3H/HeN x C58/J)F1 x C3H/HeN mice to confirm QTL using autotomy behavior in a neuroma model of neuropathic pain.
  C3H/HeN mice consistently show high levels of autotomy behavior while C58/J mice consistently show low levels. Nine polymorphic markers spaced at 3-12 cM intervals on mouse Chromosome 15 were used in the analysis.
  
  10.21.2015 Curator Note: Because Pain1 was originally mapped in J:70963 in 2001 using (AXB) and (BXA) RI strains, which differ from the cross used here, we consider the current mapping study to be a separte mapping experiment and have named the QTL Pain2.
  
  Peak linkage to the pain phenotype, Pain2, was detected at marker D15Mit68 (44.1 cM) with LOD=3.0. The 1-LOD support interval of Pain2 spans 40 cM - 48 cM, and this locus explains 5.2% of the phenotypic variance.
  
  The LOD plot shows a second peak at approximately 25 cM suggesting that another QTL affecting the pain phenotype may be present in addition to Pain2.
  
  C3H/HeN-derived alleles at Pain2 confer a dominantly inherited high pain phenotype.