Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:98907 Kemp SJ, et al., Genetic control of resistance to trypanosomiasis. Vet Immunol Immunopathol. 1996 Nov;54(1-4):239-43
• ID
  MGI:3583610

Genes

Gene	Assay Type
Tir1	resistance/susceptibility
H2	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on 400 (BALB/cOlaHsd x C57BL/6JOlaHsd)F2 animals to identify QTL associated with resistance/susceptibility to trypanosomiasis. F2 animals were innoculated with T.congolense at 10-12 weeks of age. Parental strain BALB/cOlaHsdis susceptible to infection by T.congolense whereas parental strain C57BL/6JOlaHsd is resistant. 90 polymorphic markers were initially screened in a subset of F2 animals in the extreme 5% phenotype range. Subsequently the screen was expanded to F2 animals in the extreme 16% phenotype range using 120 polymorphic markers. The 3 loci that were identified together account for 32% of the variance.
  
  Significant linkage to survival time mapped to a broad region of mouse Chromosome 17 (LOD=11). This locus is named Tir1 (trypanosome infection response 1). A two locus model yields a higher LOD score (LOD=15.1). Tir1 exhibits additive inheritance and explains 18% of the variance. The H2 locus maps to this region.
  
  Significant linkage to survival time mapped to mouseChromosome 5 with LOD=4. This locus is named Tir2 (trypanosome infection response 2). Tir2 explains 6.1% of the variance. No known candidate genes have been identified for this QTL.
  
  Significant linkage to survival time mapped to mouse Chromosome 1 withLOD=5. This locus is named Tir3 (trypanosome infection response 3). Resistanceto T.congolense shows dominant inheritance at Tir3. This QTL explains 10% of the variance. No known candidate genes have been identified for this QTL.