Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  4
• Reference
  J:93173 Pau H, et al., Characterization of a new mouse mutant, flouncer, with a balance defect and inner ear malformation. Otol Neurotol. 2004 Sep;25(5):707-13
• ID
  MGI:3586651

Genes

Gene	Assay Type
Chd7	visible phenotype
D4Mit235	PCR
D4Mit101	PCR
D4Mit171	PCR
Whl	reported elsewhere
Pou3f2	reported elsewhere

Notes

• Experiment
  The Chd7 mutation was mapped to proximal mouse Chromosome 4 near the centromere using a (C3HeB/FeJ-Flo x C57BL/6J)F1 x C3HeB/FeJ-Flo backcross population. The Chd7 mutation localized to a 6.3 cM region between D4Mit171 (6.3 cM) and the centromere. Chd7 showed tight linkage to markers D4Mit235 (1.9 cM) and D4Mit101 (3.2 cM).
  
  The Chd7 locus shows synteny to regions on human Chromosomes 6 and 8. Chd7 maps near a previously identified inner ear mutant named Whl (1.9 cM) and may be allelic. A potential candidate gene mapping near Chd7 is Pou3f2 at 6.3 cM.