Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:7191 Ozaki S, et al., Genetic regulation of erythrocyte autoantibody production in New Zealand black mice. Immunogenetics. 1983;18(3):241-54
• ID
  MGI:3608858

Genes

Gene	Assay Type
Aem1	resistance/susceptibility
Mup1	reported elsewhere
Cd72	reported elsewhere

Notes

• Experiment
  A population of (C57BL/6 x NZB)F1 x NZB backcross animals were analyzed for linkage to anti-erythrocyte autoantibody (AEA) production. Parental strain NZB exhibits AEA production starting at 4 months of age whereas parental strain C57BL/6 and F1 animals do not exhibit AEA production up to 13 months of age. A locus named Aem1 (anti-erythrocyte autoantibody modifier 1) mapped to mouse Chromosome 4 upstream of Mup1 (27.8 cM). C57BL/6J-derived alleles at Aem1 confer inhibition of AEA production with dominantinheritance. A potential candidate gene for Aem1 is Cd72 (22.5 cM, formerly Lyb2) but parental strain C57BL/6 and NZB were found to share the same allele at Cd72.