Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:33016 Kamoto T, et al., A quantitative trait locus in major histocompatibility complex determining latent period of mouse lymphomas. Jpn J Cancer Res. 1996 Apr;87(4):401-4
• ID
  MGI:3609144

Genes

Gene	Assay Type
lla	resistance/susceptibility
D17Mit21	PCR
H2	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on 114 animals from a (SL/Kh x AKR/JMs)F2 intercross to identify loci associated with lymphoma susceptibility. F2 mice were generated by mating reciprocal F1 hybreds bewteen SL/Kh and AKR/Ms. 45 polymorphic markers covering 67% of the mouse genome were used in the analysis.
  
  A locus named Tlsm1 (thymic lymphoma susceptibility 1) mapped to 60 cM mouse Chromosome 7 near D7Mit8. AKR/JMs-derived alleles at Tlsm1 confer susceptibility to thymic lymphomas with a dominant mode of inheritance.
  
  An SL/Kh-derived recessive locus at 18.6 cM on mouse Chromosome 17 near D17Mit21 was found to accelerate the latency period of all types of lymphomas (LOD=7.06). This locus is named lla (lymphoma latency acceleration.) lla overlaps with the H2 locus.