Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:15299 Mock B, et al., Genetic control of Leishmania major infection in congenic, recombinant inbred and F2 populations of mice. Eur J Immunogenet. 1993 Oct;20(5):335-48
• ID
  MGI:3611366

Genes

Gene	Assay Type
Scl1	resistance/susceptibility
Es3	reported elsewhere
Tk1	reported elsewhere

Notes

• Experiment
  Linkage analysis of animals from an (BALB/cAnPt x Rop/Le)F2 intercross and animals from several congenic strains showed that Scl1 is not linked to markers on mouse Chromosome 2, 4, 7, 8, 12, and 15. However, strain distribution pattern analysis of CXS (C=BALB/cHeAn; S=STS/A) recombinant inbred (RI) strains showed linkage of Scl1 to mouse Chromosome 11 near E3 (74 cM) and Tk1 (78 cM). Parental strain BALB/cHeAn is susceptible to infection by Leishmania major whereas parental strain STS/A is resistant.
  
  The Scl1 locus is syntenic to human Chromosome 17q22-q25.