Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:12046 Roberts M, et al., Genetic analysis of Leishmania mexicana infection in mice: single gene (Scl-2) controlled predisposition to cutaneous lesion development. J Immunogenet. 1990 Feb-Apr;17(1-2):89-100
• ID
  MGI:3611369

Genes

Gene	Assay Type
Scl2	resistance/susceptibility
Xmmv8	reported elsewhere
Lyb4	reported elsewhere
Mup1	reported elsewhere
Cd72	reported elsewhere

Notes

• Experiment
  Strain distribution pattern analysis of 12 BXD (B=C57BL/6J; D=DBA/2J) recombinant inbred (RI) strains showed linkage of susceptibility/resistance to infection with Leishmania mexicana to mouse Chromosome 4 near marker Xmmv8 (17.2 cM), Lyb4 (24.8 cM), Mup1 (27.8 cM), and Cd72 (22.5 cM). Parental strain C57BL/6J is susceptible to L. mexicana infection compared to parental strain DBA/2J. C57BL/J-derived alleles at Scl2 appear to be associated with susceptibility to L. mexicana infection.