Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:9001 Roubertoux PL, et al., Early development in mice. IV. Age at disappearance of the rooting response: genetic analysis in newborn mice. Behav Genet. 1987 Sep;17(5):453-64
• ID
  MGI:3612081

Genes

Gene	Assay Type
Adre	visible phenotype
H21	reported elsewhere
Tyrp1	reported elsewhere

Notes

• Experiment
  The rooting reponse refers to a behavior apparent at birth where the pup buries its snout underneath the mother's abdomen. This behavior disappears between 6 to 12 days after birth. In the inbred strain C57BL/6, rooting response begins to disappear at the fifth day after birth and is absent by the tenth day. In the inbred strain BALB/c, the rooting response begins to disappear at the seventh or eighth day after birth, but persists even after the twelveth day.
  
  Genetic mapping of the rooting response trait was performed using 7 CXB (C=BALB/c; B=C57BL/6) recombinant inbred (RI) strains. A single locus named Adre (age at disappearance of rooting response) mapped to mouse Chromosome 4 near H21 (38 cM) and Tyrp1 (38 cM).
  
  The existence of Adre on mouse Chromosome 4 was confirmed in the congenic strain B6.C-H21^c/ByJ. This congenic carries BALB/c-derived DNA at the H21 locus on a C57BL/6 genetic background and exhibits later disappearance of the rooting response similar to the BALB/c donor strain.