Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:7030 Yetter RA, et al., H-2-linked regulation of xenotropic murine leukemia virus expression. Proc Natl Acad Sci U S A. 1983 Jan;80(2):505-9
• ID
  MGI:3612094

Genes

Gene	Assay Type
Cxv1	visible phenotype
H2-K1	reported elsewhere

Notes

• Experiment
  Cxv1, a locus associated with high thymocyte expression of xenotropic murine leukemia virus (X-MuLV) and X-MuLV associated cell surface antigen (XenCSA), mapped near H2-K1 on mouse Chromosome 17 in a population of (AKR/J x F/St)F1 x F/St backcross animals. Parental strain F/St exhibits high X-MuLV and XenCSA expression in thymocytes. Cxv1 is recessively inherited with F/St-derived alleles conferring high X-MuLV and XenCSA thymocyte expression. Cxv1 is located approximately 1.9 cM from H2-K1.
  
  Moreover, B10.F congenic animals carrying F/St-derived DNA at H2-K1 on a C57BL/10 genetic background exhibit high X-MuLV expression similar to the levels seen in donor strain F/St. This observation supports the existence of Cxv1 on mouse Chromosome 17 near H2-K1.