Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  16
• Reference
  J:104045 Petryshen TL, et al., Two quantitative trait Loci for prepulse inhibition of startle identified on mouse chromosome 16 using chromosome substitution strains. Genetics. 2005 Dec;171(4):1895-904
• ID
  MGI:3612493

Genes

Gene	Assay Type
Eppiq1	visible phenotype
Drd3	reported elsewhere
Lsamp	reported elsewhere
Gap43	reported elsewhere
Zbtb20	reported elsewhere
Tagln3	reported elsewhere
Eppiq2	visible phenotype
Btg3	reported elsewhere

Notes

• Experiment
  QTL affecting prepulse inhibition (PPI) of the acoustic startle response mapped to mouse Chromosome 16 in a chromosome substitution strain. C57BL/6J-Chr16^A/J/Na carries a pair of A/J-derived chromosome 16 on a C57BL/6J genetic background and exhibits significantly higher PPI at 70 dB and 80 dB prepulse intensities compared to C57BL/6J.
  
  To localize the QTL, linkage analysis was performed using 87 male animals from a (C57BL/6J-Chr16^A/J/Na x C57BL/6J)F2 intercross. Forty-one single nucleotide polymorphisms (SNPs) spaced approximately 1 cM apart on chromosome 16 were used in the analysis. Two loci named Eppiq1 (elevated prepulse inhibition QTL 1) and Eppiq2 (elevated prepulse inhibition QTL 2) were identified. The proximal locus, Eppiq1, mapped to an interval between 40 Mb - 51.5 Mb (LOD=3.9) (~ 29 cM via MGI Curators) and the distal locus, Eppiq2, mapped to an interval between 78.6 Mb - 83.9 Mb (LOD=4.7) (~ 55 cM via MGI Curators). Eppiq1 and Eppiq2 are independent loci and do not interact with each other. Heterozygosity at Eppiq1 confers elevated PPI compared to animals homozygous for A/J- or C57BL/6J-derived alleles (overdominance model of inheritance). This locus explains 19% of the variance in F2 animals. Potential candidate genes for Eppiq1 with sequence variations between A/J and C57BL/6J are Drd3 (23.3 cM), Lsamp, Gap43 (29.5 cM), Zbtb20 (28.9 cM), and Tagln3. A/J-derived alleles at Eppiq2 confer elevated PPI with a recessive mode of inheritance. This locus explains 23% of the variance in F2 animals. Btg3 is the only potential candidate gene with sequence variations between A/J and C57BL/6J identified in this study for Eppiq2.