Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:1357 Kyuwa S, et al., Acute and late disease induced by murine coronavirus, strain JHM, in a series of recombinant inbred strains between BALB/cHeA and STS/A mice. Microb Pathog. 1992 Feb;12(2):95-104
• ID
  MGI:3613175

Genes

Gene	Assay Type
Pj1	resistance/susceptibility
Itgal	reported elsewhere

Notes

• Experiment
  Resistance to mouse coronavirus strain JHM (JHMV) mapped to mouse Chromosome 7 near Itgal (60 cM, formerly Ly-15) in 13 recombinant inbred (RI) strains derived from BALB/cHeA and STS/A progenitor strains. This locus is named Pj1 (paralysis, JHMV-induced 1). Parental strain BALB/cHeA is susceptible to JHMV (100% mortality 2 weeks after innoculation) whereas parental strain STS/A exhibits partial resistance (30% mortality 2 weeks after innoculation). The strain distibution pattern of 92 genes showed a correlation between Pj1 and Itgal. Since the mortality of RI animals varied between 72% and 100% and the onset of paralysis varied considerably it is thought that resistance to JHMV is under multifactorial control.