Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:5301 Ivanyi P, et al., Genetic association between H-2 gene and testosterone metabolism in mice. Nat New Biol. 1972 Aug 30;238(87):280-1
• ID
  MGI:3614828

Genes

Gene	Assay Type
Hom1	visible phenotype
H2	reported elsewhere

Notes

• Experiment
  An H2-linked locus named Hom1 (hormone metabolism 1) on mouse Chromosome 17 affects plasma testosterone concentration and testosterone binding capacity. The congenic B10.A-H2^a line carries A/Ph-derived DNA at the H2 locus (including Hom1) on a C57BL/10ScSnPh genetic background and exhibits higher plasma testosterone and testosterone binding capacity compared to C57BL/10ScSnPh. Analysis of (A/Ph x B10.A-H2^a)F2 animals showed that inheritance of A/Ph-derived alleles at the H2 locus confer increased plasma testosterone and testosterone binding capacity. This observation supports the existence of Hom1 located at approximately 23 cM on mouse Chromosome 17.