Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:5336 Ivanyi P, et al., Genetic association between a histocompatibility gene (H-2) and androgen metabolism in mice. Transplant Proc. 1973 Mar;5(1):189-91
• ID
  MGI:3614832

Genes

Gene	Assay Type
Hom1	visible phenotype
H2-K	reported elsewhere

Notes

• Experiment
  Male animals from B10.A-H2^a congenics and (A/Ph x C57BL/10ScSnPh)F2 and (AKR x C57BL/10ScSnPh)F2 intercrosses were analyzed for testes weight and vesicular gland weight. The B10.A-H2^a congenic carries A/Ph-derived DNA at the H2 locus on a C57BL/10ScSnPh genetic background. A locus named Hom1 (hormone metabolism 1) is believed to reside near H2-K and influences plasma testosterone concentration and the size of testosterone-influenced organs, such as testes, thymus, and lymph nodes. F2 animals homozygous for A/Ph-derived alleles at Hom1 exhibit increased plasma testosterone concentration, increased testosterone binding capacity, increased testes weight, and decreased vesicular gland weight compared to C57BL/10ScSnPh parentals or F2 animals homozogygousfor C57BL/10ScSnPh-derived alleles. F2 animals inheriting AKR-derived alleles at Hom1 exhibit increased testes weight and decreased vesicular gland weight compared to F2 animals homozogyous for C57BL/10ScSnPh-derived alleles, but to a lesser degree than animals homozygous for A/Ph-derived alleles at Hom1. Comparison of B10.A-5R and B10.A-2R recombinant congenic strains places Hom1 near H2-K (18.65 cM) and Ir1 on mouse Chromosome 17.