Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:11032 Brownstein DG, et al., Chromosomal locations and gonadal dependence of genes that mediate resistance to ectromelia (mousepox) virus-induced mortality. J Virol. 1991 Apr;65(4):1946-51
• ID
  MGI:3614835

Genes

Gene	Assay Type
Rmp2	resistance/susceptibility
Hc	reported elsewhere
Rmp5	resistance/susceptibility

Notes

• Experiment
  Linkage to mousepox susceptibility was mapped in 101 male animals from a (C57BL/6J x DBA/2J)F1 x DBA/2J backcross inoculated with 10⁵ PFU of mouse ectromelia virus. Inbred strain DBA/2J is highly susceptible to infection with ectromelia virus whereas inbred strain C57BL/6J is resistant. Rmp2 (resistance to mousepox 2) and Rmp3 (resistance to mousepox 3) were identified near Hc (23.5 cM) on mouse Chromosome 2 and near H2-D (19 cM) on mouse Chromosome 17, respectively. Homozygosity for DBA/2J-derived alleles at Rmp2 and Rmp3 is associated with susceptibility to ectromelia virus infection and increased post-infection mortality.
  
  10.8.2015 Curator Note: When previoulsy identified QTL are cited as confirmed or verified within the same study, using a different cross then that initially used, we have created a new QTL. We consider each distinct cross to be a separate mapping experiment. We have named the QTL identified here using the (C57BL/6NCr x DBA/2NCr)F1 x DBA/NCr backcross as Rmp5 and Rmp6 repectively.
  
  Analysis of 66 males animals from a (C57BL/6NCr x DBA/2NCr)F1 x DBA/NCr backcross had similar results. When the experiment was repeated on gonadectomized and sham-operated male backcross animals, Rmp5 and Rmp6 were shown to confer additional protection against ectromelia virus in sham-operated animals. This finding indicates that Rmp5 and Rmp6 exhibit responsiveness to hormonal sexfactors. The complement component C3 (34.3 cM) maps near Rmp6. C3 is androgen-responsive and may be a possible candidate gene.