Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
• ID
  MGI:3615277

Genes

Gene	Assay Type
Adip10	visible phenotype
D2Mit1	PCR amplified length variant
Bwtq8	visible phenotype
D2Mit92	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.
  
  On mouse Chromosome 2, Adip10 maps to 2 cM near D2Mit1 (LOD=3.5) with a 95% confidence interval spanning approximately 0 cM - 34 cM. SM/J-derived alleles at Adip10 confer increased inguinal and retroperitoneal fat pad weights with an additive mode of inheritance. Previously identified obesity QTL Obq3 (53 cM), Mob6 (49.6 cM), and Fob1 (45 cM) maps near the Adip10 interval.
  
  Bwtq8 maps to 42 cM near D2Mit92 (LOD=4) with a 95% confidence interval spanning approximately 34 cM - 78 cM. NZB/BlNJ-derived alleles at Bwtq8 confer increased lean body weight with and additive mode of inheritance. Bwq5 (81.7 cM), Nidd5 (34.5 cM), and Pbwg1 (32.8 cM) are previously identified body weight QTL located near Bwtq8.