Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  18
• Reference
  J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
• ID
  MGI:3615288

Genes

Gene	Assay Type
Obq21	visible phenotype
D18Mit4	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.
  
  Obq21 maps to 54 cM on mouse Chromosome 18 near D18Mit4 (LOD=2.5) with a 95% confidence interval spanning approximately 22 cM - 56 cM. NZB/BlNJ-derived alleles at Obq21 confer increased retroperitoneal fat pad weight with a dominant mode of inheritance.