Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:9614 Ishizaka ST, et al., Genetic control of resistance to 3-methylcholanthrene-induced T-cell lymphoma in mice. Cancer Res. 1989 Mar 1;49(5):1214-9
• ID
  MGI:3615654

Genes

Gene	Assay Type
Mclr	resistance/susceptibility
Cd8a	reported elsewhere

Notes

• Experiment
  A single locus associated with resistance to 3-methylcholanthrene (MCA)-induced T-cell lymphoma was mapped in (SWR/J x RF/J)F1 x RF/J backross animals. Parental strain SWR/J is resistant to MCA-induced lymphoma where as parental strain RF/J is susceptible. Mclr (methylcholanthrene lymphoma resistance) mapped to mouse Chromosome 6 and shows linkage to Cd8a (formerly Lyt-2) at 30.5 cM. SWR/J-derived alleles at Mclr confer dominantly-inherited resistance to MCA-induced T-cell lymphomaS.