Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:105315 de Ledesma AM, et al., Two new behavioral QTLs, Emo4 and Reb1, map to mouse Chromosome 1: Congenic strains and candidate gene identification studies. Mamm Genome. 2006 Feb;17(2):111-8
• ID
  MGI:3617015

Genes

Gene	Assay Type
Emo4	visible phenotype
Erbb4	reported elsewhere
B3gnt7	reported elsewhere
Wdfy1	reported elsewhere
Reb1	visible phenotype
Asb1	reported elsewhere
Pam	reported elsewhere
Stk25	reported elsewhere

Notes

• Experiment
  Subcongenic lines derived from B6.129P2-Il10^tm1Cgn/J were used to map behavioral QTL Emo4 (emotionality 4) and Reb1 (repetitive beam breaks 1) to 2 intervals on mouse Chromosome 1. Background strain C57BL/6J exhibits higher scores on repetitive beam breaks and increased open field activity compared to B6.129P2-Il10^tm1Cgn/J suggesting that one or more genes responsible for the modified behavioral phenotypes lie within the 129P2-derived Il10^tm1Cgn locus.
  
  Emo4 mapped to a 17.8 Mb interval on mouse Chromosome 1 between Erbb4 (68.4 Mb) and B3gnt7 (86.2 Mb). Emo4 appears distinct from Emo1 and Emo3 as both previously identified loci map at least 30 cM away. Gene expression microarray analysis identified a potential candidate gene named Wdfy1, which maps to the Emo4 QTL interval. Wdfy1 exhibits significantly increased expression in a B6.129P2-Il10^tm1Cgn/J subcongenic line R5 compared to C57BL/6J.
  
  Reb1 mapped to an 8.6 Mb interval between Asb1 (91.4 Mb) and NM_172851 (100 Mb). This locus was confirmedby linkage analysis using 750 (C57BL/6J x 129S1/SvImJ)F1 x C57BL/6J backcross animals. The Reb1 interval corresponds to a region on human Chromosome 2q36.2-36.3 that shows linkage to autism susceptibility. Gene expression microarray analysis identified 2potential candidate genes named Pam (97.6 Mb) and Stk25 (93.4 Mb). Both genes have been implicated in brain function.