Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  12
• Reference
  J:44776 Chu FF, et al., Expression and chromosomal mapping of mouse Gpx2 gene encoding the gastrointestinal form of glutathione peroxidase, GPX-GI. Biomed Environ Sci. 1997 Sep;10(2-3):156-62
• ID
  MGI:3618097

Genes

Gene	Assay Type
Gpx2
D12Mit4	PCR amplified length variant
D12Mit5	PCR amplified length variant
Ccs1	resistance/susceptibility
D12Mit6	PCR amplified length variant
D12Mit46	PCR amplified length variant

Notes

• Experiment
  Mapping of Gpx2 in a panel of backcross mice positioned it between D12Mit4 (34 cM) and D12Mit5 (37 cM) on mouse Chromosome 12. Gpx2 is in the vicinity of the colon cancer susceptibility locus Ccs1 (38 cM). Analysis of Ccs1 tumor susceptibility showed strongest linkage to D12Mit6 (45 cM), D12Mit46 (16 cM), and D12Mit4/D12Mit5. Fos (40 cM) was excluded as a candidate gene for Ccs1 due to recombination between this gene and tumor susceptibility. Gpx2 shows possible linkage to tumor susceptibility with P<0.002.