Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  12
• Reference
  J:91062 Schneider B, et al., Synergistic interaction of two independent genetic loci causes extreme elevation of serum IgA in mice. Genes Immun. 2004 Jul;5(5):375-380
• ID
  MGI:3619553

Genes

Gene	Assay Type
Miju	visible phenotype
D12Mit20	PCR amplified length variant
D12Mit8	PCR amplified length variant
Igh-Ia	reported elsewhere
Crip1	reported elsewhere
Crip2	reported elsewhere

Notes

• Experiment
  An ENU-induced mutation resulting in 40-fold increased serum IgA levels mapped to the Igj gene on mouse Chromosome 5. The mutation was created on the C3HeB/FeJ genetic background and is named Igj^Mat1. A modifying locus was mapped using 89 animals from a (C3HeB/FeJ-Igj^Mat1 x C57BL/6J)F2 intercross. 86 single nucleotide polymorphisms were used for linkage analysis. A locus named Miju (modifier of IgJ upregulation) was identified at 58 cM (107.64 Mb) on mouse Chromosome 12 near D12Mit20. Miju contributes to 71% of the phenotypic variance, and together with IgJ^Mat1 account for 91% of the variation. Miju maps to a 0.35 Mb interval between SNPb 3-4-4 and D12Mit8 (58 cM). An attractive candidate gene mapping to this interval is Igh-Ia at 58.5 cM. Crip1 (57.9 cM) and Crip2 (58.7 cM) are also potential candidates. Animals carrying Igj^Mat1 and C3HeB/FeJ-derived alleles at Miju exhibit a 40-fold increase in serum IgA.