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Mapping Data
Experiment
  • Experiment
    TEXT-QTL
  • Chromosome
    12
  • Reference
    J:91062 Schneider B, et al., Synergistic interaction of two independent genetic loci causes extreme elevation of serum IgA in mice. Genes Immun. 2004 Jul;5(5):375-380
  • ID
    MGI:3619553
Genes
GeneAlleleAssay TypeDescription
Miju visible phenotype
D12Mit20 PCR amplified length variant
D12Mit8 PCR amplified length variant
Igh-Ia reported elsewhere
Crip1 reported elsewhere
Crip2 reported elsewhere
Notes
  • Experiment
    An ENU-induced mutation resulting in 40-fold increased serum IgA levels mapped to the Igj gene on mouse Chromosome 5. The mutation was created on the C3HeB/FeJ genetic background and is named IgjMat1. A modifying locus was mapped using 89 animals from a (C3HeB/FeJ-IgjMat1 x C57BL/6J)F2 intercross. 86 single nucleotide polymorphisms were used for linkage analysis. A locus named Miju (modifier of IgJ upregulation) was identified at 58 cM (107.64 Mb) on mouse Chromosome 12 near D12Mit20. Miju contributes to 71% of the phenotypic variance, and together with IgJMat1 account for 91% of the variation. Miju maps to a 0.35 Mb interval between SNPb 3-4-4 and D12Mit8 (58 cM). An attractive candidate gene mapping to this interval is Igh-Ia at 58.5 cM. Crip1 (57.9 cM) and Crip2 (58.7 cM) are also potential candidates. Animals carrying IgjMat1 and C3HeB/FeJ-derived alleles at Miju exhibit a 40-fold increase in serum IgA.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory