Mapping Data

Experiment

• Experiment
  TEXT-Congenic
• Chromosome
  1
• Reference
  J:106114 Edderkaoui B, et al., Multiple genetic loci from CAST/EiJ chromosome 1 affect vBMD either positively or negatively in a C57BL/6J background. J Bone Miner Res. 2006 Jan;21(1):97-104
• ID
  MGI:3619593

Genes

Gene	Assay Type
Bmd1a	visible phenotype
D1Mit451	PCR amplified length variant
D1Mit106	PCR amplified length variant
Bmd1b	visible phenotype
D1Mit149	PCR amplified length variant
D1Mit355	PCR amplified length variant
Bmd1c	visible phenotype
D1Mit407	PCR amplified length variant
D1Mit17	PCR amplified length variant

Notes

• Experiment
  The bone density QTL Bmd1 on mouse Chromosome 1 was further analyzed using a series of congenic sublines derived from B6.CAST-Bmd1. 38 polymorphic markers were used to fine map the Bmd1 region spanning 100 Mb - 192 Mb. Three separate QTL designated Bmd1a, Bmd1b, and Bmd1c were identified in this interval. Female animals from the congenic subline were phenotyped for femur volumetric bone mineral density, periosteal circumference, endosteal circumference, and cortical thickness at 16 weeks of age.
  
  The interval from 100 Mb - 169 Mb is named Bmd1a (bone mineral density 1a). Animals homozygous for CAST/EiJ-derived allelesat this locus exhibit significantly increased volumetric bone mineral density (vBMD) and decreased body weight compared to animals from the C57BL/6J background strain. This locus is also associated with decreased endosteal circumference. Genetic markers D1Mit451 (81.6 cM) and D1Mit106 (85 cM) flank the Bmd1a interval. Bmd1a is syntenic to a region on human Chromosome 1q21-q23, which is significantly associated with lumbar spine BMD in humans.
  
  The interval from 172 Mb -175 Mb is named Bmd1b (bone mineral density 1b). Congenic animals homozygous for CAST/EiJ-derived alleles at this locus exhibit significantly increased vBMD and increased body weight compared to animals from the C57BL/6J background strain. This locus is also associated with decreased endosteal circumference. Genetic markers D1Mit149 (94.2 cM) and D1Mit355 (97 cM) flank the Bmd1b interval.
  
  The interval from 185 Mb - 192 Mb is named Bmd1c (bone mineral density 1c). Congenic animals homozygous for CAST/EiJ-derived alleles at this locus exhibit decreased vBMD and decreased body weight compared to animals from the C57BL/6J background strain. This locus is also associated with increased endosteal circumference. Genetic markers D1Mit407 (101.5 cM) and Tgfbm2 (formerly D1Mit17, 106.3 cM) flank the Bmd1c interval. Previously identified bone density QTL Bomd5 (101.5 cM) and Tbbmd1 (110.4 cM) overlaps with Bmd1c.
  
  A locus at 169 Mb - 171.86 Mb from D1Mit112 (91.3 cM) to D1Mit113 (93.3 cM) shows association to body weight and bone size, and a locusat 182.5 Mb - 184.6 Mb from D1Mit360 (101.2 cM) to D1Mit152 (101.5 cM) shows association to body weight.