Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:6920 Maruyama N, et al., Genetic studies of autoimmunity in New Zealand mice. IV. Contribution of NZB and NZW genes to the spontaneous occurrence of retroviral gp70 immune complexes in (NZB X NZW)F1 hybrid and the correlation to renal disease. J Immunol. 1983 Feb;130(2):740-6
• ID
  MGI:3620204

Genes

Gene	Assay Type
Agp1	visible phenotype
Agp2	visible phenotype
H2	reported elsewhere

Notes

• Experiment
  Inbred strain NZB spontaneously develops autoantibodies and glomerulonephritis similar to human lupus nephritis, whereas inbred strain NZW does not. Analysis of 123 (NZB x NZW)F1 x NZW and 113 (NZB x NZW)F1 x NZB female backcross animals reveal 2 dominant H2- linked loci associated with anti-gp70 immune complex formation. Agp1 (anti gp70 immune complex 1) is derived from the NZB genetic background whereas Agp2 (anti gp70 immune complex 2) is derived from the NZW genetic background. Loose linkage between Agp1 and H2 is estimated at 25.2 cM. The location of Agp2 is estimated to be approximately 31 cM from H2. Agp2 may act to intensify formation of gp70 immune complexes in concert with Agp1. A separate unlinked and yet unidentified locus affecting the magnitude of gp70 immune complex formation was hypothesized to exist.