Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:105481 Roubertoux P, et al., Early development in mice: II; Sensory motor behavior and genetic analysis. Physiol Behav. 1985 Nov;35(5):659-66
• ID
  MGI:3620745

Genes

Gene	Assay Type
Adre	visible phenotype
Tyrp1	reported elsewhere
H21	reported elsewhere

Notes

• Experiment
  Genetic mapping of sensory development traits was performed using 7 recombinant inbred (RI) strains derived from C57BL/6By and BALB/cBy. The parental strain C57BL/6By is considered a fast developer compared to parental strain BALB/cBy.
  
  The rooting reponse refers to a behavior apparent at birth where the pup buries its snout underneath the mother's abdomen. This behavior disappears between 6 to 12 days after birth. In the inbred strain C57BL/6By, rooting response begins to disappear at the fifth day afterbirth and is absent by the tenth day. In the inbred strain BALB/cBy, the rooting response begins to disappear at the seventh or eighth day after birth, but persists even after the twelfth day.
  
  The disappearance of rooting response showed significant strain-dependent differences (p<0.001). The strain distribution pattern mapped a single locus named Adre (age at disappearance of rooting response) to mouse Chromosome 4 near H21 (38 cM) and Tyrp1 (38 cM). C57BL/6By-derived alleles at Adre confer faster disappearance of the rooting response with a codominant mode of inheritance.
  
  Several other traits also exhibit significant strain-dependent effects but genetic loci have not yet been mapped. These traits include locomotion, righting response, hind limb placing, crossed extensor response, vibrissa placing, and bar holding.