Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:61415 Toth LA, et al., A quantitative genetic analysis of slow-wave sleep in influenza-infected CXB recombinant inbred mice. Behav Genet. 1999 Sep;29(5):339-48
• ID
  MGI:3622818

Genes

Gene	Assay Type
Srilp	visible phenotype
D6Mit316	PCR amplified length variant
D6Mit74	PCR amplified length variant
D6Mit188	PCR amplified length variant
Ghrhr	reported elsewhere
Crhr2	reported elsewhere
Cd8a	reported elsewhere

Notes

• Experiment
  Inbred strain C57BL/6J infected with influenza virus exhibits increased short wave sleep (SWS) time during the dark phase whereas BALB/cByJ exhibits normal or reduced SWS time during the light phase. The strain distribution pattern of 223 informative markers in 13 CXB (C=BALB/cByJ; B=C57BL/6J) recombinant inbred (RI) strains mapped Srilp (sleep response to influenza, light phase) to 28 cM on mouse Chromosome 6 (LRS=16.6 1 cM proximal to D6Mit316). Srilp confers increased SWS time in influenza-infectedanimals. The 95% confidence interval of Srilp spans 21 cM - 31 cM from D6Mit74 to D6Mit188. Srilp affects SWS time during circadian hours 3-6 in animals infected with influenza virus. Ghrhr (26 cM), Crhr2 (28 cM), and Cd8a (30.5 cM) are potential candidate genes mapping near Srilp. However, Cd8a may be a less likely candidate as C57BL/6J and BALB/cByJ express the same allele at Cd8a.
  
  Suggestive linkage to influenza-induced SWS time mapped to 60 cM (D14Mit266) on mouse Chromosome 14, 37 cM (D7Mit90) onmouse Chromosome 7, and 54 cM - 57 cM (D8Mit213 and D8Mit318) on mouse Chromosome 8. The locus at chromosomes 7 confers increased SWS time in influenza-infected animals during the dark phase whereas the chromosome 14 locus confers increased SWS time duringthe dark phase. The chromosome 8 locus increases SWS time during both light and dark phases. Mc1r (melanocortin 1 receptor) at 68 cM maps near the chromosome 8 locus.