Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  2
• Reference
  J:107559 Kissler S, et al., In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes. Nat Genet. 2006 Apr;38(4):479-83
• ID
  MGI:3622891

Genes

Gene
Idd5.2
Slc11a1

Notes

• Experiment
  Congenic mouse strains within the Idd5.2 (MGI: Idd5b) region of mouse Chromosome 1 were utilized to suggest that solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (Slc11a1) is a likely candidate for Idd5.2. Using RNAi (RNA interference) the authors showed that a knockdown of Slc11a1 (allele Nramp1) had a detectable effect on diabetes incidence conferred within the Idd5.2 region.