Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:108417 Suto J, Characterization of Cq3, a quantitative trait locus that controls plasma cholesterol and phospholipid levels in mice. J Vet Med Sci. 2006 Apr;68(4):303-9
• ID
  MGI:3624654

Genes

Gene	Assay Type
Cq3	visible phenotype
D3Mit102	PCR amplified length variant
D3Mit29	PCR amplified length variant
Naxe	reported elsewhere

Notes

• Experiment
  Previously identified cholesterol QTL Cq3 on mouse Chromosome 3 was further refined by mapping 93 female a/a animals from a (C57BL/6J x KK-A^y)F2 intercross. The peak LOD score for plasma free cholesterol mapped to 49.7 cM near D3Mit102 (LOD=4.5). Suggestive linkage to plasma total cholesterol, HDL cholesterol, LDL cholesterol, and phospholipids also occurs at this locus. The 95% confidence interval of Cq3 spans 47 cM - 54 cM between D3Mit29 and D3Mit102.
  
  Linkage of D3Mit102 to cholesterol traits was also examined in several other mouse crosses: (KK x RR)F2, (C57BL/6J x RR)F2, and (KK x CF1)F2. Cq3 was not detected in any of these populations.
  
  Previously identified cholesterol QTL mapping near Cq3 on mouse Chromosome 3 include Hdl35 (28 cM), Tchol1 (49.2 cM), Hdl5 (33 cM), and Hdlq21 (56 cM).
  
  A significant interaction was detected between Cq3 and Cq2 on distal mouse Chromosome 1 near D1Mit150. Cq2 is thought to be Apoa2 so the interaction between Cq3 and Apoa2/Cq2 was analyzed in 190 F2 animals. Itwas found that F2 animals homozygous for C57BL/6J-derived alleles at Cq3 and homozygous for KK-derived alleles at Apoa2/Cq2 exhibited the highest plasma total cholesterol values compared to all other genotypes.
  
  Apoa1bp is proposed as a possible candidate gene for Cq3. No differences between C57BL/6J and KK Apo1bp sequences were discovered, however Apo1bp is known to interact with Apoa2.