Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:108420 Hamano Y, et al., Genetic dissection of vasculitis, myeloperoxidase-specific antineutrophil cytoplasmic autoantibody production, and related traits in spontaneous crescentic glomerulonephritis-forming/Kinjoh mice. J Immunol. 2006 Mar 15;176(6):3662-73
• ID
  MGI:3624753

Genes

Gene	Assay Type
Sxbq2	visible phenotype
D6Mit88	PCR amplified length variant
D6Mit16	PCR amplified length variant
Tcrb	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on 420 female animals from a (C57BL/6Slc x SCG/Knj)F2 intercross to identify QTL for renal phenotypes. Parental strain SCG/Knj is derived from BXSB/Mp and MRL/Mp-Fas^lpr, and spontaneously develops crescentic glomerulonephritis and vascularitis. The Fas-^lpr mutation is largely responsible for the disease phenotype but this experiment seeks to identify non-Fas disease-associated loci. 102 polymorphic markers covering 85% of the genome at a 20 cM resolution was used for the genome scan. F2 animals were analyzed by cohorts grouped according to genotype at the Fas locus.
  
  On mouse Chromosome 6, significant linkage to total serum IgG at 12 weeks of age mapped to an interval between D6Mit88 (3.5 cM) and D6Mit16 (30.5 cM) withLOD=4.6. This locus explains is 9% of the variance and is named Sxbq2 (SGC/Knj cross B6 QTL 2). Sxbq2 also shows suggestive linkage to total serum IgM at 12 weeks of age (LOD=3.4; 7% of the variance.) C57BL/6Slc-derived alleles at Sxbq2 confer increasedIgG and IgM with an additive mode of inheritance. Tcrb at 20.5 cM is a possible candidate gene for Sxbq2.