Mapping Data

Experiment

• Experiment
  TEXT-Congenic
• Chromosome
  1
• Reference
  J:108764 Havelkova H, et al., Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects. Genes Immun. 2006 Apr;7(3):220-33
• ID
  MGI:3625966

Genes

Gene	Assay Type
Lmr8	resistance/susceptibility
Lmr8b	resistance/susceptibility
D1Mit17	PCR amplified length variant

Notes

• Experiment
  Disease phenotypes associated with Leishmania major infection were mapped in animals from (CcS-16 x BALB/cHeA)F2 and (CcS-20 x BALB/cHeA)F2 intercross populations. CcS-16 and CcS-20 are recombinant congenic (RC) strains derived from STS/A and BALB/cHeA. Animals were infected with Leishmania major after 9 weeks of age and sacrificed 8 weeks post-infection.
  
  F2 hybrids between BALB/c and CcS20/Dem and F2 hybrids between BALB/c and CcS16 were tested from clinical and immunological consequences post infection. They were genotyped with mircosatellite markers covering the STS-derived segments. Linkage analysis of differing pathological and immunological parameters indicated novel loci and novel functions for previously mapped loci.
  
  In the (BALB/c x CcS20)F2 intercross a previously identified QTL, Lmr8 was identified.
  A new function was linked with this QTL:
  Lmr8b, mapping with D1Mit17 (106.3 cM) , corrected p=0.00237 was associated with spontaneous proliferation of spleen cells post infection, BALB/c alleles at this locus were associated with higher proliferation.