Mapping Data

Experiment

• Experiment
  TEXT-Congenic
• Chromosome
  8
• Reference
  J:108764 Havelkova H, et al., Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects. Genes Immun. 2006 Apr;7(3):220-33
• ID
  MGI:3625974

Genes

Gene	Assay Type
Lmr10	susceptibility/resistance
Lmr10b	susceptibility/resistance
Lmr10c	susceptibility/resistance
D8Mit125	PCR amplified length variant
D8Mit54	PCR amplified length variant

Notes

• Experiment
  Disease phenotypes associated with Leishmania major infection were mapped in animals from (CcS-16 x BALB/cHeA)F2 and (CcS-20 x BALB/cHeA)F2 intercross populations. CcS-16 and CcS-20 are recombinant congenic (RC) strains derived from STS/A and BALB/cHeA. Animals were infected with Leishmania major after 9 weeks of age and sacrificed 8 weeks post-infection.
  
  F2 hybrids between BALB/c and CcS20/Dem and F2 hybrids between BALB/c and CcS16 were tested from clinical and immunological consequences post infection. They were genotyped with mircosatellite markers covering the STS-derived segments. Linkage analysis of differing pathological and immunological parameters indicated novel loci and novel functions for previously mapped loci.
  
  In the (BALB/c x CcS20)F2 intercross a previously mapped QTL, Lmr10 mapping with markers D8Mit125 (19.5 cM) and D8Mit54 (31 cM), was identified. New individual functions were linked with this QTL:
  Lmr10b was linked with splenomegaly at D8Mit125, corrected p=0.00354 and D8Mit54, corrected p=0.0000319. BALB/c alleles at this locus were associated with more severe
  splenomegaly.
  Lmr10c was linked with skin lesions at D8Mit125 and D8Mit54, corrected p=0.00000681 at both markers. BALB/c alleles at this locus were associated with larger lesions.