Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  X
• Reference
  J:102750 Parsons CA, et al., Interspecies synteny mapping identifies a quantitative trait locus for bone mineral density on human chromosome Xp22. Hum Mol Genet. 2005 Nov 1;14(21):3141-8
• ID
  MGI:3628459

Genes

Gene	Assay Type
Sbmd5	visible phenotype

Notes

• Experiment
  Linkage analysis performed on animals from a (SAMP6 x AKR/J)F2 intercross mapped a QTL associated with spinal bone mineral density between 4 and 6 months of age to an interval on mouse Chromosome X between 145 Mb and 158 Mb (P=0.01). This locus is designated Sbmd5 (spinal bone mineral density 5).
  
  Sbmd5 is sytenic to a 10.9 Mb region on proximal human Chromosome X. SNP analysis was performed on possible candidate genes found within the human syntenic region. Two SNPs located in intron 6 of the PIR gene showed association with bone mineral density in a cohort of 1053 women. Pir is located near the QTL peak and the center of the Sbmd5 interval in mouse.