Mapping Data

Experiment

• Experiment
  TEXT-Congenic
• Chromosome
  7
• Reference
  J:109580 Korff S, et al., Fine mapping of Dyscalc1, the major genetic determinant of dystrophic cardiac calcification in mice. Physiol Genomics. 2006 May 16;25(3):387-92
• ID
  MGI:3639102

Genes

Gene	Assay Type
Abcc6	resistance/susceptibility
D7Nds5	PCR amplified length variant
D7Mit230	PCR amplified length variant
Fgf21	reported elsewhere
Myod1	reported elsewhere
Abcc6	reported elsewhere
Sult2b1	reported elsewhere
Abcc8	reported elsewhere
Otog	reported elsewhere

Notes

• Experiment
  Dyscalc1 (21 cM) on mouse Chromosome 7 was confirmed by construction of congenic inbred strains B6.C3-(D7Mit56-D7Mit230) and B6.C3-(D7Nds5-D7Mit230). Background strain C3H/HeNCrlBr is resistant to dystrophic cardiac calcification (DCC) whereas donor strain C57BL/6NCrlBr is susceptible. Both congenics were susceptible to DCC after myocardial freeze-thaw injury thus confirming the existence of Dyscalc1.
  
  Haplotype analysis refined Dyscalc1 to a 0.76 Mb interval between Fgf21 (23.5 cM; 37.9 Mb) and Myod1 (40.46 Mb). This region contains 31 known and putative genes. Gprc2a-rs1 (20 cM), Bax (23 cM), and Hrc (20 cM) were excluded as candidate genes, and Abcc6 was proposed as a new potential candidate. Mutations in human ABCC6 result in pseudoxanthoma elasticum,an elastic tissue disorder involving cardiovascular calcification.
  
  The majority of the Dyscalc1 region contains 3 large ancestral haplotype blocks shared among 3 susceptible inbred strains (C3H/HeJ, DBA/2J, 129S1/SvImJ) and corresponded to Sult2b1, Abcc8, and Otog (28 cM).