Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:109795 Kenney-Hunt JP, et al., Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37
• ID
  MGI:3639959

Genes

Gene	Assay Type
Lbn4	visible phenotype
D5Mit32	PCR
Tbx5	reported elsewhere
Dtx2	reported elsewhere
Fzd9	reported elsewhere
Fzd10	reported elsewhere
Zfp11	reported elsewhere
Eln	reported elsewhere
Epo	reported elsewhere
Fbxo24	reported elsewhere
Taf6	reported elsewhere

Notes

• Experiment
  Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci listed in the reference are reported here.
  
  On mouse Chromosome 5, linkage to humerus length in males mapped to 78 cM near D5Mit32 (LPR=2.6). This locus is named Lbn4 (long bones 4). The confidence interval spans 90 cM - 130 cM. Potential candidate genes mapping near Lbn4 include Tbx5 (65 cM), Dtx2, Fzd9 (75 cM), Fzd10, Zfp11, Eln (75 cM), Epo (78 cM), Fbxo24, and Taf6.