Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:109795 Kenney-Hunt JP, et al., Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37
• ID
  MGI:3639961

Genes

Gene	Assay Type
Lbn6	visible phenotype
D7Mit21	PCR
Fgf21	reported elsewhere
Zscan2	reported elsewhere
Zfp536	reported elsewhere
Fut1	reported elsewhere
Fut2	reported elsewhere
Stard5	reported elsewhere
St8sia2	reported elsewhere
Kif7	reported elsewhere
Bod4	visible phenotype
D7Nds1	PCR
Zfp592	reported elsewhere
Fzd4	reported elsewhere
Org5	visible phenotype
D7Mit148	PCR

Notes

• Experiment
  Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci listed in the reference are reported here.
  
  On mouse Chromosome 7, linkage to tibia length, Lbn6 (long bones 6), mapped to 28 cM near D7Mit21 (LPR=7.39). The Lbn6 confidence interval spans 14 cM - 54 cM. Potential candidate genes mapping near Lbn6 include Fgf21, Zscan2 (formerly Zfp29), Zfp536, Fut1 (23.2 cM), Fut2 (23.2 cM), Nr2f1 (*note: this gene maps to chromosome 13 according to MGD data), Stard5 (41.2 cM), St8sia2 (formerly Siat8b), and Kif7.
  
  Bod4 (bone length and organs 4), mapped to 43 cM near D7Nds1 (LPR=23.17). This locus is associated with necropsy body weight, liver weight, and femur and ulna length. The confidence interval spans 44 cM - 54 cM. Previously identified QTL Adip3 (46.6 cM) may be identical to Bod4. Potential candidate genes for Bod4 include Zscan, Zfp592, Fzd4, Stard5, and Kif7.
  
  Heart weight and kidney weight, Org5 (organ weight 5), mapped to 46 cM near D7Mit148 (LPR=20.92). The Org5 interval spans 50 cM - 56 cM.