Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  8
• Reference
  J:109795 Kenney-Hunt JP, et al., Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37
• ID
  MGI:3639962

Genes

Gene	Assay Type
Lbn7	visible phenotype
D8Mit293	PCR
Comp	reported elsewhere
Fkbp8	reported elsewhere
Zfp42	reported elsewhere
Irf2	reported elsewhere
Fbxo8	reported elsewhere
Bod5	visible phenotype
D8Mit8	PCR

Notes

• Experiment
  Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci listed in the reference are reported here.
  
  On mouse Chromosome 8, Lbn7 (long bones 7) mapped to 29 cM near D8Mit293 (LPR=5.52). This locus is associated with necropsy body weight and ulna length. The confidence interval spans 0 cM- 32 cM. Previously identified QTL Adip4 (32 cM) may be identical to Lbn7. Potential candidate genes mapping near Lbn7 include Comp (33 cM), Spock3, Fkbp8, Zfp42 (24 cM), Irf2, Eif2s2 (*note: data in MGD places this gene on chromosome 2), and Fbxo8.
  
  Bod5 (bone length and organs 5) mapped to 42 cM near D8Mit8 (LPR=7.03). This locus is associated with liver and kidney weights and femur, tibia, and humerus lengths. The confidence interval spans 22 cM - 52 cM. Potential candidate genes for Bod5 include Comp, Spock3, and Fkbp8.