Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  9
• Reference
  J:109795 Kenney-Hunt JP, et al., Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37
• ID
  MGI:3639974

Genes

Gene	Assay Type
Lbn8	visible phenotype
D9Mit19	PCR
Bmp5	reported elsewhere
Pth1r	reported elsewhere
Tfdp2	reported elsewhere
Rasa2	reported elsewhere
Sox14	reported elsewhere
Trex1	reported elsewhere
Scap	reported elsewhere
Gpx1	reported elsewhere
Usp4	reported elsewhere

Notes

• Experiment
  Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci listed in the reference are reported here.
  
  On mouse Chromosome 9, linkage to tibia, humerus, and ulna lengths mapped to 37 cM near D9Mit19 (LPR=2.04). This locus is named Lbn8 (long bones 8).The QTL interval spans 28 cM - 72 cM.Potential candidate genes mapping near Lbn8 include Bmp5, Pthr1 (58 cM), Tfdp2, Rasa2, Sox14 (53 cM), Trex1, Scap (58 cM), Gpx1 (57 cM), and Usp4 (60 cM).