Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  16
• Reference
  J:109795 Kenney-Hunt JP, et al., Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37
• ID
  MGI:3639987

Genes

Gene	Assay Type
Bod10	visible phenotype
D16Mit2	PCR
Fgd4	reported elsewhere
Tbx1	reported elsewhere
Trmt2a	reported elsewhere
Fgf12	reported elsewhere
Apod	reported elsewhere
Pak2	reported elsewhere
Ciita	reported elsewhere

Notes

• Experiment
  Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci listed in the reference are reported here.
  
  On mouse Chromosome 16, Bod10 (bone length and organs 10) mapped to 14 cM near D16Mit2 (LPR=2.61). This locus is associated with necropsy body weight, spleen weight, and tibia and ulna lengths (male-specific). The Bod10 confidence interval spans 0 cM -16 cM. Previously identified QTL Skl7 (14.1 cM) may be identical to Bod10. Potential candidate genes mapping near Bod10 include Fgd4, Tbx1 (11.35 cM), Htf9c (10.9 cM), Fgf12 (19.6 cM), Apod (21.2 cM), Pak2 (21.2 cM), Gng5 (*note: MGD data places this gene on chromosome 3), and C2ta.