Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:110209 Mao JH, et al., Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8125-30
• ID
  MGI:3640322

Genes

Gene
Skts14
Skts1
Tgfb1

Notes

• Experiment
  Using a panel of markers from 306 (NIH/Ola x outbred Mus spretus)F1 x NIH/Ola (NSP) backcross animals, to identify skin tumor susceptibility QTL, two linkage peaks were indicated.
  
  The proximal locus, Skts14, mapped to app 14.0Mb on Chromosome 7, peaking at Tgfb1 a very strong candidate gene for influencing cancer risk.
  
  Previous studies [J:27733] demonstrated the existance of a skin tumor susceptibility locus, Skts1, on proximal chromosome 7 that controls papilloma development. The current study using the same cross, confimed this QTL.