Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  18
• Reference
  J:109156 Liu H, et al., Identification and developmental expression analysis of a novel homeobox gene closely linked to the mouse Twirler mutation. Gene Expr Patterns. 2006 Aug;6(6):632-6
• ID
  MGI:3653208

Genes

Gene
Mkx
D18Mit19
D18Mit166
Zeb1

Notes

• Experiment
  The authors used an intersubspecific backcross to identify the genomic region containing the Tw gene. Genotyping of nearly 600 mouse progeny from (Tw/CAST C57BL/6) crosses using microsatellite markers from proximal region of mouse Chromosome 18 was informative in mapping Tw. Mapping results localized the Tw locus to a 4.3 Mb genomic region between D18Mit19 and D18Mit166. This region included a Riken gene 9430023B20Rik which was renamed to Mkx. The authors suggests that the developmental expression pattern indicates that MKx (Irxl1) is a good candidate gene for the Twirler (Tw) gene.