Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  10
• Reference
  J:111677 Delahunty KM, et al., Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition. Endocrinology. 2006 Aug;147(8):3915-23
• ID
  MGI:3664264

Genes

Gene	Assay Type
Igf1sl2	visible phenotype
Igf1	reported elsewhere
Kitl	reported elsewhere
Socs2	reported elsewhere
Elk3	reported elsewhere

Notes

• Experiment
  Previously identified QTL Igf1sl2 (51 cM) on mouse Chromosome 10 was narrowed to a 18.3 Mb interval containing 148 genes using congenic line analysis. C3H/HeJ-derived alleles at Igf1s2 spanning a 57 Mb interval were introgressed onto a C57BL/6J genetic background for 10 generations. The congenic line, named B6.C3H-Igf1sl2, displays increased serum and skeletal IGF-1, increased trabecular bone volume fraction, more trabeculae, and increased osteoclast number at 16 weeks of age, thus confirming the presence of Igf1sl2.
  
  Seven nested congenic sublines were derived from B6.C3H-Igf1sl2. Phenotype analysis localized Igf1sl2 to an interval between Igf1 (48 cM) and Kitlg (57 cM). Soc2 (52 cM) and Elk3 (51 cM) are potential candidate genes mapping to this interval. Previously identified QTLs Vtbt (51 cM), Bgeq8 (57 cM), Si5lq4 (69.9 cM), and Igfbp3q2 (46 cM) are located near Igf1sl2.