Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  4
• Reference
  J:94456 Yu Q, et al., ENU induced mutations causing congenital cardiovascular anomalies. Development. 2004 Dec;131(24):6211-23
• ID
  MGI:3686524

Genes

Gene	Assay Type
vsd	visible phenotype
D4Mit196	PCR
D4Mit288	PCR
tga	visible phenotype
D4Mit312	PCR
D4Mit189	PCR

Notes

• Experiment
  ENU mutatgenesis was performed on C57BL/6J males. Potential mutations were propgated and crossed onto a (C57BL/6J x C3H) hybrid background. Forty-three polymorphic markers were used to map new mutations, and ultrasound imaging was used to screen mutant fetuses with cardiovascular defects. Two recessive mutations mapped to mouse Chromosome 4. A mutation causing ventricular septal defect, vsd, mapped to a 17 Mb interval between D4Mit196 (12.1 cM) and D4Mit288 (28.6 cM). Persistent truncus arteriosis, pta, mapped to a 5.7 Mb interval between D4Mit312 (69.8 cM) and D4Mit189 (71 cM).