Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  10
• Reference
  J:108841 Torkamanzehi A, et al., Identification of informative strains and provisional QTL mapping of amphetamine (AMPH)-Induced locomotion in recombinant congenic strains (RCS) of mice. Behav Genet. 2006 Nov;36(6):903-13
• ID
  MGI:3695448

Genes

Gene	Assay Type
Amdt2	visible phenotype
D10Mit282	PCR amplified length variant
D10Mit16	PCR amplified length variant
D10Mit106	PCR amplified length variant
D10Mit214	PCR amplified length variant
Oprm1	reported elsewhere
Esr1	reported elsewhere
Ccn2	reported elsewhere

Notes

• Experiment
  Genetic loci associated with amphetamine-induced locomotor activation were mapped using 34 recombinant congenic strains (RCSs) derived from C57BL/6J and A/J. Eight to 15 animals from each RCS were injected with 5 mg/kg amphetamine solution and measured for total distance traveled in 10 minute intervals. Parental strain C57BL/6J exhibits a greater amount of amphetamine-induced locomotor activation compared to A/J. Six hundred twenty microsatellite markers were used for genetic analysis.
  
  Significant linkage to amphetamine-induced locomotor activation mapped to 12 cM - 13 cM on mouse Chromosome 1 near D1Mit231 and D1Mit372a (P=0.001). This locus is designated Amdt1 (amphetamine distance traveled 1). Homozygosity for C57BL/6J-derived alleles at Amdt1 confers greater locomotor activation.
  
  Highly significant linkage to amphetamine-induced locomotor activation mapped to 12 cM - 19 cM on mouse Chromosome 10 near D10Mit282, D10Mit16, D10Mit106, and D10Mit214. This locus is named Amdt2 (amphetamine distance traveled 2). C57BL/6J-derived alleles at Amdt1 confer increased locomotor activation. Potential candidate genes mapping near this regioninclude Oprm1 (8 cM), Esr1 (12 cM), and Ctgf (17 cM). Amdt2 colocalizes with a morphine preference QTL named Mop2 at 12 cM and overlaps with a fear response QTL, Lrnx8 at 16 cM.
  
  Suggestive linkage to amphetamine-induced locomotor activity was identified at 9 cM on mouse Chromosome 9 near D9Mit90 (P=0.0355) and 50.5 cM on mouse Chromosome 20 near DXMit173 (P=0.0261). *Note-Mapping data in MGI places DXMit173 on mouse Chromosome X.*