Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:41574 Swardson CJ, et al., Plasmodium yoelii: resistance to disease is linked to the mtv-7 locus in BALB/c mice. Exp Parasitol. 1997 Jun;86(2):102-9
• ID
  MGI:3696564

Genes

Gene	Assay Type
Mlrrq	resistance/susceptibility
Mtv7	reported elsewhere
Spta1	reported elsewhere

Notes

• Experiment
  Malaria resistance mapped near the Mtv7 locus (96 cM) on mouse Chromosome 1 in BALB.D2-Mtv7 congenic animals. Background strain BALB/c is susceptible to infection with Plasmodium yoelii and develops severe anemia and a high degree of parasitemia whereas the congenic BALB.D2-Mtv7 is resistant (mild anemia and low degree of parasitemia). The malaria resistance locus, designated Mlrrq (malaria resistance QTL) is linked to but independent of Mtv7.
  
  Mtv7 results in deletion of T cells bearing Vbeta6, 7, 8.1,and 9 T cell receptor elements. Neonatal BALB/c (susceptible) animals given 10⁸ BALB.D2-Mtv7 spleen cells within 24 hours after birth did not exhibit increased resistance to P. yoelli. In addition, athymic nude mice given T cells from BALB/c or BALB.D2-Mtv7 animals did not display differences in the course of infection. Therefore, the data suggests the Mtv7 locus is not involved in P. yoelli resistance, but a nearby linked gene, Mlrrq, is responsible for the effect. Spna1 at 95.4 cM is a potential candidate gene for Mlrrq.