Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  8
• Reference
  J:117548 Lin E, et al., Mapping of the Plasmodium chabaudi resistance locus char2. Infect Immun. 2006 Oct;74(10):5814-9
• ID
  MGI:3697102

Genes

Gene	Assay Type
Char2a	resistance/susceptibility
D8Mit27a	PCR amplified length variant
D8Mit266	PCR amplified length variant
Char2b	resistance/susceptibility
D8Mit14	PCR amplified length variant
D8Mit56	PCR amplified length variant

Notes

• Experiment
  Congenic line analysis was used to refine the Char2 locus on mouse Chromosome 8. Nine recombinant congenic strains were created by repeatedly backcrossing B6.C3-Char2 to parental strain C57BL/6J. Animals from each subcongenic line were tested for malariaresistance by injection with red blood cells infected with Plasmodium chabaudi. The Char2 region appears to harbor 2 separate QTLs, designated Char2a and Char2b. Char2a is located between D8Mit27a (33 cM) and D8Mit266 (43 cM). Char2b is located between D8Mit14 (67 cM) and D8Mit56 (73 cM). C3H/HeJ-derived alleles at Char2a and Char2b appear to confer susceptibility to malaria.