Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:117547 Vitarius JA, et al., Identification of quantitative trait loci affecting body composition in a mouse intercross. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19860-5
• ID
  MGI:3697840

Genes

Gene	Assay Type
Bdln7	visible phenotype
Lbm11	visible phenotype
Lbm14	visible phenotype
Bw26	visible phenotype
Ftm1	visible phenotype
Abfm1	visible phenotype
Abfm2	visible phenotype
Mofp1	visible phenotype
Mofp5	visible phenotype
Rfpw1	visible phenotype
Bmc1	visible phenotype
Bmc7	visible phenotype
Bmd28	visible phenotype
Bmd32	visible phenotype

Notes

• Experiment
  Genetic loci associated with body composition were mapped using 369 animals from a (C57BL/6J x CASA/Rk)F2 intercross. A panel of 255 polymorphic markers at an average spacing of 5.9 cM was used for the genome scan. Parental strain C57BL/6J displays decreased activity and increased body weight, lean tissue mass, abdominal fat mass, body length, bone mineral density (BMD), bone area, and bone mineral content (BMC) compared to parental strain CASA/Rk. Males from C57BL/6J display increased body mass index (BMI) and total body fat tissue mass (FTM) compared to males from CASA/Rk.
  
  On mouse Chromosome 2, linkage to body length (Bdln7, LOD=4), and lean body mass (Lbm11, LOD=6.13) mapped to 34 cM. Linkage to lean body mass in males mapped to 36 cM and is named Lbm14 (LOD=4.19). Linkage to body weight mapped to 34 cM (LOD=5.21) and is named Bw26. Linkage to total body fat tissue mass (Ftm1, LOD=4.2) mapped to 60 cM and linkage to abdominal fat mass mapped to 62 cM (Abfm1, LOD=4.13) and 87 cM (Abfm2, LOD=3.88). Linkage to mesenteric and omental fat pad weight mapped to 66 cM (Mofp1, LOD=4.32), and to 87 cM for males (Mofp5, LOD=3.48). Linkage to retroperitoneal fat pad weight (Rfpw1, LOD=5.14) mapped to 96 cM. Linkage to bone mineral content mapped to 40 cM (Bmc1, LOD=3.87), and to 37 cM for males (Bmc7, LOD=3.5). Linkage to bone mineral density mapped to 40 cM (Bmd28, LOD=4.09) in both sexes, and to 37 cM (Bmd32, LOD=4.34) in females.