Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  9
• Reference
  J:117547 Vitarius JA, et al., Identification of quantitative trait loci affecting body composition in a mouse intercross. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19860-5
• ID
  MGI:3698449

Genes

Gene	Assay Type
Bdln8	visible phenotype
Bdln9	visible phenotype
Lbm12	visible phenotype
Lbm15	visible phenotype
Bw29	visible phenotype
Ba2	visible phenotype
Ba5	visible phenotype
Bmc4	visible phenotype
Bmc9	visible phenotype
Bmd34	visible phenotype

Notes

• Experiment
  Genetic loci associated with body composition were mapped using 369 animals from a (C57BL/6J x CASA/Rk)F2 intercross. A panel of 255 polymorphic markers at an average spacing of 5.9 cM was used for genome scan. Parental strain C57BL/6J displays decreasedactivity and increased weight, lean tissue mass, abdominal fat mass, body length, bone mineral density (BMD), bone area, and bone mineral content (BMC) compared to parental strain CASA/Rk. Males from C57BL/6J display increased body mass index (BMI) and total body fat tissue mass (FTM) compared to males from CASA/Rk.
  
  On mouse Chromosome 9, linkage to body length (Bdln8, LOD=4.8) mapped to 59 cM. Linkage to body length in males (Bdln9, LOD=4.42) mapped to 72 cM. Linkage to lean body mass (Lbm12, LOD=5.88)mapped to 63 cM and linkage to lean body mass in males (Lbm15, LOD=5.08) mapped to 71 cM near D9Mit151. Homozygosity for C57BL/6J-derived alleles at Lbm15 confers increased lean body mass in males. Linkage to body weight in males (Bw29, LOD=4.15) mapped to 71 cM. Linkage to bone area (Ba2, LOD=5.07) mapped to 59 cM and linkage to bone area in males (Ba5, LOD=5.49) mapped to 63 cM. Linkage to bone mineral content mapped to 61 cM (Bmc4, LOD=4.96) in both sexes and to 65 cM (Bmc9, LOD=5.64) in males only. Bone mineral density in males, named Bmd34, mapped to 65 cM.