Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:118951 Litherland SA, et al., Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction. J Immunol. 2005 Oct 1;175(7):4561-5
• ID
  MGI:3702137

Genes

Gene	Assay Type
Idd4.3	resistance/susceptibility
Csf2	reported elsewhere

Notes

• Experiment
  Congenic line analysis was used to investigate genetic loci involved in diabetes susceptibility, macrophage STAT5 dysfunction, and GM-CSF production. Diabetes-resistant congenic line NOD.LC11 carries C57L-derived DNA on mouse Chromosome 11 encompassing the Idd4 locus and Stat5a/Stat5b/Stat3 genes on a NOD genetic background. Congenic subline NOD.LC11f carries C57L-derived DNA at Csf2 (29 cM), Idd4a (43 cM), and Idd4b (48 cM) while NOD.LC11b carries C57L-derived DNA only at Csf2. Both lines exclude C57L-derived Stat5a/Stat5b/Stat3 genes. NOD.LC11b exhibits a greater incidence of diabetes (27%) compared to NOD.LC11f (19%) indicating the presence of a diabetes susceptibility locus near Csf. This locus is named Idd4c and also exhibits linkage to decreased GM-CSF production and increased STAT5 phosphorylation in unactivated macrophages.